Registration Dossier
Registration Dossier
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EC number: 948-534-1 | CAS number: 1639208-51-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Quality of whole database:
- Maximum Tolerated Acute Dose Oral /Rat <60 mg/kg
Maximum Tolerated Acute Dose Oral /Dog 50 mg/kg
In single dose studies in dogs and rats, morbidity was associated with a dose of 80 and >100 mg/kg NBI-98854, respectively
Additional information
Justification for classification or non-classification
Single oral gavage administration in the dog and rat were tolerated up to 15 mg/kg/day for NBI-98854.
Several of the clinical signs observed in animals were consistent with the intended pharmacological effect of the drug which is to deplete monoamines (primarily dopamine) in the nervous system.
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