Registration Dossier
Registration Dossier
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EC number: 252-907-8 | CAS number: 36196-44-8
Endpoint summary
Administrative data
Description of key information
Sufficient data from QSAR models to classify according to acute oral/dermal endpoints.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- see category report attached under "full study report"
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Species:
- rat
- Route of administration:
- other: Oral
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 834 mg/kg bw
- Based on:
- other: read across
- Dose descriptor:
- LD50
- Effect level:
- 0.002 other: mol/kg
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The estimated acute oral LD50 is 834 mg/kg bw
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 834 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- see category report attached under "full study report"
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Species:
- other: Rabbit
Rat - Dose descriptor:
- LD50
- Effect level:
- 1 969.158 other: mg/kg bdwt
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The estimated acute dermal LD50 is <2000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 969 mg/kg bw
Additional information
Justification for classification or non-classification
The criteria for classification as dermal and oral acute toxicant category 4 are fullfiled by assessing these endpoint using adequate QSAR tools.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
