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EC number: 218-691-4
CAS number: 2216-52-6
Based on the QSAR prediction done using the Danish (Q)SAR Database, the skin sensitization for (+)-Neomenthol was estimated to be not sensitizing on guinea pig and humans. Thus it can be concluded that the substance, (+)-Neomenthol has no skin sensitization effects.
Hence, (+)-Neomenthol can be considered to be not sensitizing to skin.
Table showing allergic dermatitis estimation by three different models i.e, Leadscope, battery and SciQSAR & CASE Ultra,the average results was given by the fourth model i.e, Battery model.
Allergic Contact Dermatitis in Guinea Pig and Human
IN = inside applicability domain, NEG = Negative; INC = Inconclusive; POS = Positive, OUT = outside applicability domain
Skin sensitization effects were estimated by four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra used within Danish QSAR database for (+)-Neomenthol. Based on estimation, no skin sensitization reactions were observed in guinea pigs and humans. Therefore, (+)-Neomentholwas considered to be not sensitizing.
Various studies have been summarized to ascertain the degree of skin sensitization caused by (+)-Neomenthol in living organisms. These studies include in vivo experiments on guinea pigs and humans for the target chemical and structurally similar chemicals. The experimental results have been also been compared with the estimated results.
Skin sensitization effects were estimated by four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra used within Danish QSAR database for (+)-Neomenthol. Based on estimation, no skin sensitization reactions were observed in guinea pigs and humans. Therefore, (+)-Neomenthol was considered to be not sensitizing.
This is supported by the results of an Open Epicutaneous test was conducted in guinea pigs (male and female) to determine the skin sensitization potential of the structurally similar chemicals.
The pretest was performed to determine the primary irritating threshold concentration of test substances at various concentrations (e.g, 100, 30, 10 and 3%). In this test, a single application of 0.025 ml of each test concentration was simultaneously performed on one of the areas measuring 2 cm2 of the flank skin previously clipped and marked with a circular stamp. Reactions are read 24 h after the application of the test material.
On day 1 during induction, 0.1 ml of undiluted test chemical was applied to an area measuring 8 cm2 on the clipped flank skin of the guinea pigs. The applications are repeated daily for 3 weeks or done 5 times weekly during 4 weeks, usually on the same skin sites. The application sites were left uncovered and the reactions, if continuous daily applications were performed, can be read 24 h after each application, or at the end of each week. To determine whether or not contact sensitization was induced, all groups of guinea pigs previously treated for 21 days, as well as 10 untreated, or only pretreated with the vehicle, controls are tested on days 21 and 35 on the contralateral flank with the test material. This test was performed by applying with a pipette 0.025 ml of chemical to skin areas measuring 2 cm2. The reactions were read after 24, 48 and/or 72h.
Both of the structurally similar chemicals failed to induce dermal sensitization reactions in guinea pigs after the challenge exposure. Hence, they can be considered to be not sensitizing.
Based on the results from the available studies for the target as well as structurally similar chemical, and applying the weight of evidence approach, (+)-Neomenthol can be considered to be not sensitizing to skin.
Based on the available studies for the target chemical as well its structurally similar chemicals, (+)-Neomenthol can be considered to be not sensitizing to skin.
It can be classified under the category “Not Classified” as per CLP regulation.
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