α-chloro-2-fluorotoluene

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

November 21, 2019 - March 18, 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential thermal analysis

Test material

Test material information

Constituent 1

Reference substance name:

Reference substance 001

Cas Number:

345-35-7

Test material form:

liquid

Specific details on test material used for the study:

None

Results and discussion

Boiling point

Key result

Boiling pt.:

>= 160 - <= 163 °C

Remarks on result:

other: Measured under atmospheric conditions.

Any other information on results incl. tables

A DSC measurement with the test item in an aluminium crucible with a hole showed an exothermal effect starting at approximately 115 °C. No further endothermal or exothermal effects were observed up to the final temperature (500 °C). The mass loss after the DSC measurements amounted to 51 %.

The results of the DSC measurements are summarized in Table 3.

Table 3: Boiling point (DSC measurement in open aluminium crucibles)

Ident No.	Test item / mg	Starting temperature / °C	Final test temperature / °C	Temperature range (endo-thermal) / °C	Onset  (boiling) / °C	Crucible	Observations after the measurement
38916	8.08	25	500	--	--	Aluminium with a hole	Black residue in the crucible, mass loss: 51 %

As in the determination of the vapour pressure by dynamic method (see report No.:PS20190384-3) the test item was heated up to 166 °C without any apparent decomposition, it was assumed that the test item reacted with the aluminium of the crucible. This observation was in accordance with the information in chapter 10.3 of the safety data sheet (SDS-Number 122000001459, 2-Fluorbenzylchlorid; version 8.0) stating that the test item reacts with many metals.

Therefore, two DSC measurements were performed in open glass crucibles as follows:

The test item was cooled down to -80 °C with a cooling rate of 1 K/min, -80 °C were kept for 60 min and afterwards the test item was heated up to 300 °C with a heating rate of 10 K/min. During heating up, the measurements showed an endothermal effect (boiling) after melting in the temperature range of 100 °C to 195 °C. The onset temperature (see Table 2) was derived from the intersection of the tangent line with the highest slope of the endothermal peak with the baseline.

The results of the DSC measurements in open glass crucibles are summarized in Table 4.

 

Table 4: Boiling point (DSC measurements in open glass crucibles)

Ident No.	Test item / mg	Starting temperature / °C	Final test temperature / °C	Temperature range (endo-thermal) / °C	Onset (melting) / °C	Crucible	Observations after the measurement
39070	13.21	-80	300	100 – 190	160.63	Glass (open)	Mass loss 100 %
39072	13.51	-80	300	100 – 195	162.10	Glass (open)	Mass loss 100 %

A decomposition of the test item was not observed in open class crucibles up to 300 °C.

The test item had a boiling range under atmospheric conditions of 160 °C to 163 °C.

Applicant's summary and conclusion

Executive summary:

The test item had a boiling range under atmospheric conditions of 160 °C to 163 °C.