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EC number: 243-020-7 | CAS number: 19395-41-6
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- GLP compliance:
- no
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- α-phenylpiperidine-2-acetic acid
- EC Number:
- 243-020-7
- EC Name:
- α-phenylpiperidine-2-acetic acid
- Cas Number:
- 19395-41-6
- Molecular formula:
- C13H17NO2
- IUPAC Name:
- α-phenylpiperidine-2-acetic acid
- Test material form:
- solid: granular
Constituent 1
Results and discussion
Particle sizeopen allclose all
- Percentile:
- D90
- Mean:
- 35.13 µm
- Remarks on result:
- other: st.dev. not specified
- Percentile:
- D50
- Mean:
- 9.01 µm
- Remarks on result:
- other: st.dev. not specified
- Percentile:
- D10
- Mean:
- 2.39 µm
- Remarks on result:
- other: st.dev. not specified
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- > 0.142 - < 0.159 µm
- Distribution:
- 0.02 %
- No.:
- #2
- Size:
- > 0.502 - < 0.564 µm
- Distribution:
- 0.29 %
- No.:
- #3
- Size:
- > 1.589 - < 1.783 µm
- Distribution:
- 0.95 %
- No.:
- #4
- Size:
- > 6.325 - < 7.096 µm
- Distribution:
- 4.3 %
- No.:
- #5
- Size:
- > 25.179 - < 28.251 µm
- Distribution:
- 2.6 %
- No.:
- #6
- Size:
- > 100.237 - < 112.468 µm
- Distribution:
- 0.12 %
Any other information on results incl. tables
Tests were conducted dispersing the sample labelled asRitalinic Acidusing the specific sampling unit called SCIROCCO 2000. The results of the determination on the sample labelled as Ritalinic Acid are shown in the attached figure.
The figure shows the average volume diameter as well as that for which the accumulative particle size distribution assumes a respective value of 90%, 50% and 10% in addition to the differential distribution for each fraction and the corresponding graph as well as the measurement parameters and the indications of the powder sample and the operator.
In Table 1, the average volume diameter is found as well as that for which the accumulative particle size assumes a respective value of 90%, 50% and 10%.
Table 1_Characteristic diameters of the particle size distribution on the sample Ritalinic Acid
SAMPLE |
D[4,3] micrometre |
d(90%) micrometre |
d(50%) micrometre |
d(10%) micrometre |
Ritalinic Acid |
14,70 |
35,13 |
9,01 |
2,39 |
Applicant's summary and conclusion
- Conclusions:
- Particle size distribution of the substance is : D90 = 35.13 micrometre; D50 = 9.01 micrometre; D10 = 2.39 micrometre.
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