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EC number: 230-408-6
CAS number: 7098-80-8
The testsubstance was not mutagenic in the Salmonella typhimurium
/Escherichia coli reverse mutation assay.
SOLUBILITY: No precipitation of the test substance was found with and
without S9 mix.
TOXICITY: A weak bacteriotoxic effect was observed depending on the
strain and test conditions at a concentration of 5200 μg/plate
MUTAGENICITY: A relevant increase in the number of his+ or trp+
revertants (factor ≥ 2: TA 100, TA 98 and E.coli WP2 uvrA or factor ≥ 3:
TA 1535 and TA 1537) was not observed in the standard plate test or in
the preincubation test without S9 mix or after the addition of a
The test substance Isopropylidenglycerolmethacrylate (IPGMA) was tested
for its mutagenic potential based on the ability to induce point
mutations in selected loci of several bacterial strains, i.e. Salmonella
typhimurium and Escherichia coli, in a reverse mutation assay. Strains
tested TA 1535, TA 100, TA 1537, TA 98 and E. coli WP2 uvrA, dose range
33 μg - 5200 μg/plate (SPT) and 33 μg - 5200 μg/plate (PIT) Standard
plate test (SPT) and preincubation test (PIT) both with and without
metabolic activation (liver S9 mix from induced rats). No precipitation
of the test substance was found with and without S9 mix. A weak
bacteriotoxic effect was observed depending on the strain and test
conditions at a concentration of 5200 μg/plate. A relevant increase in
the number of his+ or trp+ revertants (factor ≥ 2: TA 100, TA 98 and
E.coli WP2 uvrA or factor ≥ 3: TA 1535 and TA 1537) was not observed in
the standard plate test or in the preincubation test without S9 mix or
after the addition of a metabolizing system.
Under the experimental conditions of this study, the testsubstance
Isopropylidenglycerolmethacrylate (IPGMA) is not mutagenic in the
Salmonella typhimurium/Escherichia coli reverse mutation assay in the
absence and the presence of metabolic activation.
on the results, the test item is no subject to classification and
labelling according to Regulation (EC) No 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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