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EC number: 618-771-2
CAS number: 915725-52-9
Screening for the eye irritancy potential of N-t-butylglycine acid
chloride HCl using the Bovine Corneal Opacity and Permeability test
This report describes the ocular irritation properties of
N-t-butylglycine acid chloride HCl on an isolated bovine cornea. The
possible ocular irritancy of N-t-butylglycine acid chloride HCl was
tested through topical application for 240 ± 10 minutes.
The study procedures described in this report were based on the most
recent OECD and EC guideline.
Batch # 11560006 of N-t-butylglycine acid chloride HCl was a beige
powder. The test substance was applied as a 16.7% and a 20% (w/w)
solution (750 µl) directly on top of the corneas in the first and second
The negative control responses of the opacity and permeability values
were less than the upper limits of the laboratory historical range
indicating that the negative control did not induce irritancy on the
corneas. The mean in vitro irritancy scores of the positive control (20%
(w/v) Imidazole) were 94 and 105, in the first and second experiment,
respectively and within the historical positive control data range. It
was therefore concluded that the test conditions were adequate and that
the test system functioned properly.
The mean in vitro irritancy score was 37 after 240 minutes of treatment
with a 16.7% (w/w) solution of N-t-butylglycine acid chloride HCl and 24
after 240 minutes of treatment with a 20% (w/w) solution of
N-t-butylglycine acid chloride HCl. Since the mean in vitro irritancy
score for N-t-butylglycine acid chloride HCl was below 55.1 after 240
minutes treatment in both experiments N-t-butylglycine acid chloride HCl
is considered to be not severe irritant or corrosive.
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