Barium phosphinate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

data is from authoritative database.

Data source

Reference

Reference Type:

other: Authoritative database

Title:

Dermal irritation study of test substance

Author:

U. S. National Library of Medicine

Year:

2018

Bibliographic source:

HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC, 2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

other: the 49 CFR Part 173.240 method from the US Hazardous Materials Regulations

Principles of method if other than guideline:

The potential of test chemical to induce skin irritation or corrosion was assessed in adult New Zealand white rabbits (3 males and 3 females) using the 49 CFR Part 173.240 method from the US Hazardous Materials Regulations.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium phosphinate

EC Number:

231-669-9

EC Name:

Sodium phosphinate

Cas Number:

7681-53-0

Molecular formula:

H3O2P.Na

IUPAC Name:

Sodium hypophosphite

Test material form:

solid

Details on test material:

- Name of test material: sodium phosphinate
- IUPAC name: Sodium hypophosphite
- Molecular formula: NaO2P
- Molecular weight: 87.9778 g/mole
- Smiles notation: [Na+].[O-]P=O
- InChl: 1S/Na.H3O2P/c;1-3-2/h;3H2,(H,1,2)/q+1;/p-1
- Substance type: Inorganic
- Physical state: Solid

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

- Age at study initiation: adult

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Remarks:

(intact or abraded sites)

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

500 mg

Duration of treatment / exposure:

4 hours

Observation period:

24, 48 and 72 hours

Number of animals:

6 (3 males and 3 females)

Details on study design:

- Area of exposure: shaved backs
SCORING SYSTEM: According to the criteria laid down in EC regulation 1272/2008/EC

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Remarks:

Erythema and edema

Basis:

mean

Time point:

24/48/72 h

Score:

1

Reversibility:

not specified

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

A slight erythema (scoring value 1) was observed in all animals at the 24-hour reading and was still persistent in 1 out of 3 animals treated onto an intact skin and 2 out of 3 animals treated on an abraded area at the 72-hour reading. Only one animal with intact skin showed a slight oedema (soring value 1) at the 72-hour reading.

Other effects:

No data

Applicant's summary and conclusion

Interpretation of results:

other: Not irritating

Conclusions:

Based on the observation and according to the criteria laid down in CLP (Reg 1272/2008/EC), the test chemical was considered as non-irritant to the skin of adult New Zealand white rabbits.

Executive summary:

The dermal irritation test was conducted to determine the skin irritation potential of the given test chemical in adult New Zealand white rabbits (3 males and 3 females) using the 49 CFR Part 173.240 method from the US Hazardous Materials Regulations. the test method used was comparable to the OECD 404 guideline issued in 1981. During the study, the rabbits were dermally exposed to 500 mg of test chemical for 4 hours on prepared shaved backs. 3 animals received the test chemical onto an intact skin while the remaining received the test chemical onto an abraded area. The test substance was held in contact with the skin by means of an occlusive dressing. Cutaneous reactions were observed 24, 48 and 72 hours after removal of the dressing. The test substance caused slight erythema (scoring value 1) in all animals at the 24-hour reading and was still persistent in 1 out 3 animals treated onto an intact skin and 2 out 3 animals treated on an abraded area at the 72-hour reading. Only one animal with intact skin showed a slight oedema (soring value 1) at the 72-hour reading. Thus, according to the criteria laid down in EC regulation 1272/2008/EC and based on the observations, the test chemical was considered as non-irritant to the skin.