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EC number: 207-353-1
CAS number: 464-45-9
A repeated dose toxicity study (oral route) was performed on isobornyl
acetate according to a similar method to OECD guideline 408. The
substance was dissolved in corn oil and administered daily to rats by
stomach tube in doses: 0 (control), 15, 90 or 270 mg/kg body weight/day
during 13 weeks. There were no differences between treated and control
animals in the rate of body-weight gain, the food intake or the results
of haematological investigations. In male rats given 270 mg/kg bw/day
there was a decrease in renal concentrating ability, an increase in
water intake, exfoliation of renal tubular cells, increased kidney
weight and vacuolation of the renal tubular cells. Signs of
nephrotoxicity were also seen with daily doses of 90 mg/kg bw/day.
Vacuolation of the epithelium of the intrahepatic bile-duct and increase
in liver weights were found at 270 mg/kg bw/day. The caecum were also
enlarged at this dosage level. The no-effect level (NOEL) was found to
be 15 mg/kg bw/day.
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