Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: A scientific review (peer reviewed). No data on GLP.

Data source

Reference
Reference Type:
review article or handbook
Title:
Monographs on fragance raw materials: L-Borneol
Author:
Opdyke D L J
Year:
1978
Bibliographic source:
Food and Cosmetics Toxicology. Vol. 16, pp. 655-656.

Materials and methods

Principles of method if other than guideline:
No data on test method
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(1S-endo)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
EC Number:
207-353-1
EC Name:
(1S-endo)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
Cas Number:
464-45-9
Molecular formula:
C10H18O
IUPAC Name:
1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
Test material form:
solid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
other: Not classified (CLP Regulation EC no. 1272/2008)
Conclusions:
The acute dermal LD50 value of the test substance was >2000 mg/kg bw in rabbits.
Executive summary:

According to the peer reviewed article, the acute dermal LD50 value of the test substance was >2000 mg/kg bw in rabbits.