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EC number: 207-353-1
CAS number: 464-45-9
The metabolism of borneol was studied by the analysis of incubations of
in vitro-prepared rat liver microsomes. Male Sprague-Dawley rats, aged
approximately 50 days and weighing 230–250 g, were used for the study. A
typical incubation mixture was performed in a shaking water bath at 37°C
for 30 min and consisted of 2.5 mg/mL rat liver microsmal protein, 0.1M
potassium phosphate buffer (pH 7.4), 1mM NADPH, and 325μM Bornel with a
final volume of 1 mL. Gas chromatography (GC)–mass spectrometry (MS)
method was developed for the identification of Borneol and its
metabolites. Four phase I metabolites were detected: M1 (m/z 152)
confirmed as camphor, M2 (m/z 122) proposed as the de-methylated and
de-hydrated metabolite, M3 (m/z 170) and M4 (m/z 170) both proposed as
the hydroxylated metabolites.
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