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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Limited documentation. No information on analytical purity of test substance given.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
Limited documentation. No information on analytical purity of test substance given.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(1R)-1-isopropyl-4-methyl-cyclohex-3-en-1-ol
Cas Number:
20126-76-5
Molecular formula:
C10H18O
IUPAC Name:
(1R)-1-isopropyl-4-methyl-cyclohex-3-en-1-ol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
600, 1220, 2470 and 5000 mg/kg bw
No. of animals per sex per dose:
10 animals per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Remarks:
calculated
Effect level:
1 300 mg/kg bw
Based on:
test mat.
95% CL:
840 - 2 100
Mortality:
600 mg/kg bw: 1/10 animals died
1220 mg/kg bw: 4/10 animals died
2470 mg/kg bw: 9/10 animals died
5000 mg/kg bw: 10/10 animals died
Mortality occurred in all animals within 24 h.
Clinical signs:
other: 600 mg/kg bw: ataxia, lethargy, tremors, chromorhinorrhea, chromodacryorrhea 1220 mg/kg bw: lethargy, ptosis, piloerection, chromorhinorrhea 2470 mg/kg bw: salivation, chromorhinorrhea, ataxia 5000 mg/kg bw: coma and death
Gross pathology:
600 mg/kg bw: dark lungs (1/10), dark liver (1/10), dark kidneys (1/10) and areas of redness in intestines (1/10)
1220 mg/kg bw: dark lungs (4/10), dark liver (4/10), dark kidneys (2/10) and areas of redness in intestines (4/10) and motteled kidneys (3/10)
2470 mg/kg bw: dark lungs (9/10), dark liver (8/10), dark kidneys (2/10), areas of redness in intestines (6/10), dried blood around eyes (3/10), yellow exudate from nose and mouse (3/10), yellow portions of intestines (3/10), red portions of stomach (3/10), bloody urine in bladder (2/10), red exudate from mouth (2/10) and mottled kidneys(1/10)
5000 mg/kg bw: dark lungs (9/10), dark liver (7/10), dark kidneys (3/10) and areas of redness in intestines (6/10)

Applicant's summary and conclusion

Interpretation of results:
other: Acute Tox. 4 according to Regulation (EC) No 1272/2008
Conclusions:
In this acute oral toxicity study a LD50 value of 1300 mg/kg bw was derived in rats.