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EC number: 276-333-2
CAS number: 72089-08-8
Table 1. Measured concentrations of the test item during the
Start of the exposure interval
24 h end of the exposure interval
24 h start of the exposure interval
48 h end of the exposure interval
Geometric mean measured test item concentration
Dilution level of the saturated solution [%}
Not measured due to 100% mortality after 24 h
Meas. conc. = measured concentration of the test item, single
determinations, enrichments and dilution factors taken into account
% = percentage of the initially measured
concentration of the test item
LOQ = limit of quantification of the
analytical method (0.01 mg test item/L)
1) = due
to technical reasons the samples had to be reanalyzed on 2017-02-23
(after the expiry date 2017-03-17)
2) = Reinjection
on 2017-03—23 (sample prepared on 2017-03-17)
* = saturated solution
Table 2. Immobilization rates after 24 h and 48 h of exposure
(n = 20, in 4 replicates).
Geometric mean measured concentration of the test item [mg/L]
Mean value in absolute numbers
Mean value in %
100% after 24 h
The effects of the test item to aquatic invertebrates were determined in
an acute immobilization test according to OECD guideline 202 in a closed
system without headspace under semi-static conditions (renewal: 0 and 24
h). Daphnia were exposed to five dilution levels of a saturated solution
for 48 h. The concentration of the test item was analytically verified
The measured concentrations of the test item in the fresh media ranged
from 0.165 to 9.78 mg/L. The concentrations in the old media (24 h and
48 h) were in the range of 76 - 93% of the initially measured
concentrations. The derived EC50 (48 h) was 1.34 mg/L (geometric mean
EC50 (48 h) = 1.34 mg/L (geom. mean measured conc., D. magna, OECD
There is one study available, in which the toxicity of the
substance to aquatic invertebrates was investigated according to OECD
guideline 202 and GLP.
In a semi-static test, Daphnia magna was exposed to an undiluted
saturated solution with a nominal loading of 10 mg test item/L and five
dilution levels prepared from the saturated solution in a geometric
series with a dilution factor of 2.2 (nominal: 1.94 – 45.5%) for 48 h.
To reduce contact with air and losses of the test item by evaporation,
the test was conducted in a closed system without headspace. The
concentrations of the test item were analytically verified by GC-MS in
fresh media (0 and 24 h) and aged media (24 and 48 h) in all
concentration levels and the control.
The measured concentrations of the test item in fresh media (at 0
and 24 h) ranged from 0.165 to 9.78 mg/L. The measured concentrations in
the aged media (at 24 and 48 h) were 76 – 93% of the initially measured
concentrations. The geometric mean measured concentrations were: 0.153,
0.355, 0.821, 1.78, 4.12, 9.25 mg/L.
After 48 h, immobility was observed at concentration levels above
0.153 mg/L. The derived EC50 (48 h) is 1.34 mg/L (geometric mean
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