Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
Remarks:
Type of genotoxicity: chromosome aberration
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 474 (1997)
GLP compliance:
yes
Type of assay:
micronucleus assay

Test material

Details on test material:
Batch no : A4305 05008

Test animals

Species:
other: mus, CD-1

Administration / exposure

Route of administration:
inhalation
Vehicle:
Edenol (epoxised soya bean oil).

Results and discussion

Test results
Toxicity:
yes
Remarks:
Doses producing toxicity: Toxic signs at the highest tested concentration of 600 ppm.
Additional information on results:
Observations:
No lethal effects; no cytotoxicity (PCE/NCE).

Applicant's summary and conclusion

Conclusions:
Interpretation of results: negative

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