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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
5 November 1998 - 6 January 1999
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
Directive 92/69/EEC
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
ca. 26.4 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
120 g/L
Temp.:
20 °C
pH:
ca. 2.4
Details on results:
Mean concentration = 26.4 g/l at 20.0 +/- 0.5 C
Range = 26.1 to 26.5 g/l

The concentration (g/l) of test material in the sample solutions is shown in the following table:

 Sample number  Time shaken at ~30 C (hrs)  Time equilibrated at 20 C (hrs)  Concentration (g/l)  Solution pH
 1  24  24  26.6  2.4
 2  48  24  26.1  2.4
 3  72  24  26.5  2.4
Conclusions:
The water solubility of BMS 214702-01 has been determined to be 26.4 g/l solution at 20.0 +/- 0.5 C.
Executive summary:

The water solubility of BMS 214702-01 has been determined using the flask method, Method A6 of Commission Directive 92/69/EEC. The water solubility was determined to be 26.4 g/l solution at 20.0 +/- 0.5 C.

Description of key information

The water solubility of BMS 214702-01 has been determined using the flask method, Method A6 of Commission Directive 92/69/EEC. The water solubility was determined to be 26.4 g/l solution at 20.0 +/- 0.5 C.

Key value for chemical safety assessment

Water solubility:
26.4 g/L
at the temperature of:
20 °C

Additional information