Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-170-2 | CAS number: 557-34-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: This study meets generally accepted scientific principles, so it is acceptable for assessment. No data on GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1986
Materials and methods
- Principles of method if other than guideline:
- The sex related response to zinc acetate was investigated in mice. Male and female adult ICR-mice were administered single intraperitoneal injections of test substance. The median lethal dose (LD50) was calculated 1, 3, 5, 7, and 14 days following administration.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Zinc di(acetate)
- EC Number:
- 209-170-2
- EC Name:
- Zinc di(acetate)
- Cas Number:
- 557-34-6
- Molecular formula:
- C2H4O2.1/2Zn
- IUPAC Name:
- zinc diacetate
- Details on test material:
- - Name of test material (as cited in study report): Zinc acetate, ZnAc2
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 10-20 weeks
- Weight at study initiation: 32-35 g
- Diet (e.g. ad libitum): Freely available all time.
- Water (e.g. ad libitum): Freely available all time.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- Stock solution of ZnAc2 was prepared the day of injection (day 0) with serial dilutions made and used for the injection series.
- Doses:
- 35, 42, 50, and 60 mg/kg bw.
- No. of animals per sex per dose:
- 10 male and 10 female animals per dose group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 42 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 37.5 - 47.1
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 42 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 38.2 - 46.2
- Mortality:
- Nearly all deaths occurred by day seven, with few deaths occurring between 7 and 14 days.
- Gross pathology:
- Autopsies revealed extreme vasodilation of abdominal vessels and cardiac arrest in diastole.
Any other information on results incl. tables
Ther LD50 for male and female mice treated with Zinc Acetate was 42.0 mg/kg bw.
Applicant's summary and conclusion
- Conclusions:
- Ther LD50 for male and female mice treated with Zinc Acetate was 42.0 mg/kg bw.
- Executive summary:
The sex related response to zinc acetate was investigated in mice. Male and female adult ICR-mice were administered single intraperitoneal injections of test substance. The median lethal dose (LD50) was calculated 1, 3, 5, 7, and 14 days following administration.
Nearly all deaths occurred by day seven, with few deaths occurring between 7 and 14 days.
Ther LD50 for male and female mice treated with Zinc Acetate was 42.0 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
