Sulfuric acid, mono-C14-16 (even numbered)-alkyl esters, sodium salts

Toxicity to soil macroorganisms except arthropods

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to soil macroorganisms except arthropods: short-term

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

other: proposed procedure for toxicity testing with the earthworm Eisenia foetida (Savigny) in artificial soil (USA, 14 d), UBA Berlin 3/1984

Principles of method if other than guideline:

mortality of Eisenia fetida in artificial soil spiked with test substance

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Eisenia fetida

Animal group:

annelids

Study type:

laboratory study

Substrate type:

artificial soil

Total exposure duration:

14 d

Reference substance (positive control):

not specified

Duration:

14 d

Dose descriptor:

EC0

Effect conc.:

> 1 000 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality

Reference 2

Endpoint:

toxicity to soil macroorganisms except arthropods: short-term

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Refer to the Category Approach Justification document provided in IUCLID6 Section 13

Reason / purpose for cross-reference:

read-across source

Duration:

14 d

Dose descriptor:

EC0

Effect conc.:

> 1 000 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality

Remarks on result:

other: Source, key, 68955-20-4, 1988

Description of key information

14d EC50 (Eisenia fetida, mortality) > 1000 mg/L (nominal concentration, UBA Berlin 3/1984)

Additional information

In accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to another structurally related category members was conducted. Read-across data available for C16-18AS Na (CAS 68955-20-4) were used.

One reliable short-term study with Eisenia fetida is available for C16-18AS Na (CAS 68955-20-4, Steber 1988). The study followed the procedure for toxicity testing with the earthworm Eisenia foetida (Savigny) in artificial soil (14 d; UBA Berlin 3/1984). Earthworms were exposed to the test substance for 14 days in artificial soil. The 14-day EC0 value based on mortality was above 1000 mg a.i./kg soil d.w.

The substance is not supposed to be directly applied to soil and further is readily biodegradable. Hence in case of indirect exposure to soil, the substance is expected to rapidly degrade. Therefore soil is not expected to be a compartment of concern.

Besides, the Equilibrium Partitioning Method was used to calculate the PNECs values for the terrestrial compartment. The substance exhibits an adsorption coefficient (log Koc) below 5 and is readily biodegradable. In case of exposure to soil, the substance is expected to rapidly degrade, thus the hazard to terrestrial organisms is negligible. Hence, the Equilibrium Partitioning Method is sufficient to calculate the PNECs values for the terrestrial compartment according to the “Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance”, Section 7.11.6 Integrated Testing Strategy for Effects on Terrestrial Organisms (ECHA 2017).