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EC number: 274-572-7
CAS number: 70331-94-1
The following information is available for review:
The substance is not readily biodegradable achieving 0-2% in 28 days.
Due to high water insolubility (1.5 μg/l), it is not possible to assess
the potential for hydrolysis by testing. The substance is, however, a
stable organic molecule and is, therefore, considered to not potentially
hydrolyse in the environment.
The substance potentially screens as persistent.
The log Pow has been determined to be 8.1. The substance is highly
insoluble in water (1.5 μg/l). The high log Pow is likely to be due in
part to the hydrophobic nature of the molecule but is well outside the
criteria by which that substance is considered to present a potential
The substance has a water solubility of 1.5 μg/l which clearly limits
the bioavailability towards aquatic organisms. Furthermore, due to the
high adsorption potential (log Koc > 5.63) it is expected that the
substance will bind to sewage sludge and be removed from the water
phase. In total, the concentrations in the environmental water phase are
expected to be very low and not relevant for bioaccumulation.
The calculated BCF value is 713.4 L/kg wet-wt estimated by QSAR
modelling. These values support the above-mentioned assessment that the
substance is not expected to significantly accumulate in aquatic
No evidence of accumulation was noted in the repeated dose study
conducted on the substance.
The substance does not screen as "B" based on the high log Kow value and
The substance is highly insoluble in water. In consequence exposure to
three aquatic species (algae, daphnia and fish) have been investigated
at nominal concentrations. The toxicological examination of freshwater
fish, daphnia and algae provided the following results:
· LC50 > 100 mg/l in fish
· EC50 > 100 mg/l in daphnia
· EC50 > 100 mg/l in algae
The substance is not classified on the basis of these results and no
further toxicological examination is considered appropriate to determine
that hazard of the substance.
The substance has been assessed for genetic toxicity utilising in vitro
assays with and without metabolic activation. All endpoints demonstrated
a lack of mutagenic response.
The reproduction/developmental screening test provided a result NOAEL
1000 mg/kg bw/day and showed no substance related effects on parents or
On the basis of the genetic and reproduction/developmental toxicity data
available, in addition to the repeated dose toxicity data the substance
is not classified for this endpoint.
The data from the 90-day mammalian toxicity oral repeated dose study
achieved a NOAEL >2000 mg/kg/day. The substance is not classified on the
basis of this data and no further toxicological examination is
considered necessary for hazard assessment.
The substance demonstrates no toxicity in any of the test endpoints
The substance does not screen as PBT of vPvB on the basis of the
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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