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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic information is given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Guidelines of the Department of Transportation (D.O.T.), Code of Federal Regulations, Title 49, Part 173
GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Aluminium, compound with nickel (1:1)
EC Number:
234-439-6
EC Name:
Aluminium, compound with nickel (1:1)
Cas Number:
12003-78-0
Molecular formula:
Al.Ni
IUPAC Name:
aluminum - nickel (1:1)
Test material form:
solid: particulate/powder
Details on test material:
dark grey fine powder

Test animals

Species:
rabbit
Strain:
other: New Zealand
Sex:
not specified
Details on test animals or test system and environmental conditions:
- healthy albino rabbits
- weighing ca. 3 kg
- animals were individually housed in stainless steel supended cages.

Administration / exposure

Type of coverage:
other: see details on study design
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
The test item was applied at 2mg/kg of body weight to the shaved skin and wrapped with an impervious band which has left in place for 24 hours.
Duration of exposure:
Animals were observed for mortality for up to 48 hours.
Doses:
2 mg / kg /bw
No. of animals per sex per dose:
5 animals / abraded skin
5 animals / intact skin

same doses to all, see above
Control animals:
no
Details on study design:
After a 7-day acclimation period, ten rabbits were clipped free of fur over the entire upper back area. Rabbits showing signs of dermal irritation or lesions were replaced. Five of the tesat sites were abraded by making a series of five parallel superficial scracthes in the dermis; the reminaing five were left intact.

Body weights were recorded at dosing.
Treatment sites were evaluated for signs of erythema or edema according to the Draize Scoring System.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 mg/kg bw
Based on:
test mat.
Mortality:
No deaths were noted up to 48 hours after application.
Clinical signs:
other: No changes were noted in skin condition during the test period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information
Conclusions:
The 48 hour LD50 is calculated at greater than 2 mg/kg in the rabbit.