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EC number: 245-844-2
CAS number: 23726-93-4
OECD Guideline 203, GLP, key study, validity 1:96h-LC50 (Danio rerio) = 1.09 mg/L (95% CL: 1.08 - 1.10 mg/L)
assess the short-term toxicity of the registered substance to fish, one
study is available.
study (NOACK, 2015) was assessed as the key study and was performed on
the registered substance according to OECD Guideline 203 with GLP
statement. In this study, the test substance was
exposed to zebra fish Danio rerio at
nominal concentrations of 0.342, 0.751, 1.65, 3.64 and 8.00 mg/L
(corresponding to geometric mean measured concentrations of 0.263,
0.664, 1.34, 3.47 and 7.30 mg/L) under semi-static conditions for 96
hours, plus one control without test substance. The
determination of the test substance concentrations was carried out via
GC-MS. Evaluation was carried out from freshly prepared media after 0
and 72 h and from the corresponding 24 h aged test media after 24 and 96
h. The measured concentration of the test substance in freshly prepared
media after 0 and 72 hours of exposure were in the range of 85 to 113 %
of the nominal values. The measured concentrations in the corresponding
24 h aged test media were in the range of 45 to 91 % of the nominal
96 hours of exposure, no mortality was observed at the nominal
concentrations of 0, 0.342 and 0.751 mg/L, and 100% mortality was
observed at 1.65, 3.64 and 8.00 mg/L. Therefore, the test
substance was found to cause lethal effects to zebrafish after 96 hours
at a nominal concentration of 1.65 mg/L. The 96h-LC50 based on nominal
concentrations was determined at 1.23 mg/L (95% CL: 1.22 -1.24 mg/L),
corresponding to a geometric mean measured value of 1.09 mg/L (95% CL:
1.08 -1.10 mg/L).
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