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EC number: 245-844-2
CAS number: 23726-93-4
OECD Guideline 305, non-GLP, key study, validity 2:BCF = 14 to 56Not bioaccumulable
To assess the bioaccumulation potential of
the registered substance, one key study is available.
This study was performed according
to the OECD Guideline 305 but without GLP statement in order to
determine the extent of accumulation of the registered substance by the
carp, Cyprinus carpio, during the exposure period of 8 weeks. Two
nominal exposure levels of the test substance were used (10 µg/L for the
Level 1 and 1 µg/L for the Level 2; each of means exposure
concentrations were about 70% of nominal value). This study was
performed at 25 ± 2 °C and the dissolved oxygen concentration was
6.4-7.1 mg/L (level 1) and 6.8-7.3 mg/L (level 2). The test media
analysis was performed twice a week (16 times in total during the test
period) and the test fish analysis was performed every two weeks (4
times in total during the test period) using Gas chromatograph-Mass
spectrometer (GC-MS). The bioconcentration factors (BCFs) after 8
weeks can be understood to have reached to plateau. The BCFs of the test
substance were in the range of 14 to 40 at Level 1 and 15 to 56 at Level
2, respectively. No significant difference among the BCFs at two levels
was observed and no abnormality in behaviour and appearance was
observed. In conclusion, the Bioconcentration factor (BCF) of the test
substance is comprised between 14 and 56.
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