Silicon

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: extensive evaluation report by OECD

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other: evaluation

Title:

SIDS initial assessment report for SIAM 19. Synthetic amorphous silica and silicates.

Author:

OECD

Year:

2004

Bibliographic source:

UNEP Publications, Berlin.

Materials and methods

Type of study / information:

other: human - medical data / skin contact

Endpoint addressed:

skin irritation / corrosion

Principles of method if other than guideline:

OECD evaluated availabe data on human skin contact with amorphous silica, only one study available,
workers had intensive and regular contact with silica

Test material

Test material information

Constituent 1

Reference substance name:

amorphous silica

IUPAC Name:

amorphous silica

Results and discussion

Results:

signs of irritation which resulted to skin dryness

Applicant's summary and conclusion

Conclusions:

The adverse effect was reversible.

Executive summary:

OECD (2004) evaluated that there one study on human skin contact with synthetic amorphous silica. More than 200 workers were in conctact with amorphous silica. This resulted to skin dryness which was a reversible effect and was able to be controlled by regular use of skin-protection ointment..