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EC number: 265-182-8
CAS number: 64742-79-6
A complex combination of hydrocarbons obtained from a petroleum stock by treating with hydrogen to convert organic sulfur to hydrogen sulfide which is removed. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C13 through C25 and boiling in the range of approximately 230°C to 400°C (446°F to 752°F).
studies identified in which the skin sensitising potential of other gas
oils was investigated in male Hartley guinea pigs that were dermally
exposed to hydrodesulfurised middle distillate (Klimisch scores = 2, API
the first key study, the test material was administered at a
concentration of 25% v/v in paraffin oil for the induction phase and at
10% v/v in paraffin oil for the challenge application. The
test material induced slight erythema but no oedema following the
challenge application. In
the second study, the test material was administered undiluted for the
induction phase and at a concentration of 10% v/v in paraffin oil for
the challenge application. The
test material elicited well-defined erythema and slight oedema during
the induction phase but no response upon challenge. Based
on the results of these studies, neither sample of hydrodesulfurised
middle distillate was a dermal sensitiser in guinea pigs.
Migrated from Short description of key information:
Two studies identified that investigated skin sensitisation of hydrodesulphurised middle distillate. Data show that other gas oils do not induce or elicit allergic skin reactions in the guinea pig (OECD 406).
Justification for selection of skin sensitisation endpoint:
One of two studies with different samples of hydrodesulphurised middle distillate. Both studies negative. Key study selected as it used a higher induction concentration.
Gas Oils do not meet the criteria for classification as sensitising to
the skin according to EU CLP Regulation (EC No. 1272/2008).
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