2-hydroxyethyl methacrylate

Endpoint summary

Description of key information

LC50 fish (96h): > 100 mg/l

EC50 Daphnia magna (48h): > 380 mg/l

NOEC Daphnia magna (21d): 24.1 mg/l

EC50 algae (72h): 345 mg/l (growth rate)

NOEC algae (72h): 160 mg/l (growth rate)

EC10 microorganisms: 100 mg/l

Additional information

Aquatic toxicity studies with 2-hydroxyethyl methacrylate were conducted in fish, invertebrates, and algal species.

For fish in the key study 2-hydroxyethyl methacrylate was tested in a limit test at 100 mg/l acc. OECD 203 under semi-static conditions with Oryzias latipes. LC50 (96h) was > 100 mg/l. (Environmental Agency of Japan, 1997).

Supporting information is available with a test acc. ASTM E-35 under flow through condition with Pimephales promelas. LC50 (96h) was 227 mg/l (Geiger, 1986). Additionally a prolonged test was performed by the Environmental Agency of Japan (1997) for 14 days with Oryzias latipes under flow through conditions. LC50 (14d) was > 100 mg/l. NOEC (14d was 25 mg/l.

For invertebrates, one reliable acute and chronic study with Daphnia magna was available for assessment. The EC50 was 380 mg/L, based on the acute 48-hour exposure. Based on the chronic 21-day exposure, the NOEC for reproduction was 24.1 mg/L.

For the algal species, one reliable study with Selenastrum capricornutum as the test species was available for assessment. The EC50 and NOEC for the freshwater species were 345 mg/L and 160 mg/L, respectively and based on growth rate following 72-hours of exposure.

Toxicity to microorganisms testing is waived for 2-hydroxyethyl methacrylate since it is readily biodegradable at an application concentration (100 mg/L) in an OECD 301 C (MITI) test, which is greater than the predicted environmental concentration (PEC) in the influent of the sewage treatment plant (STP).

Summarized, the lowest aquatic toxicity value for 2-hydroxyethyl methacrylate was the NOEC of 24.1 mg/L, based on the 21-day chronic toxicity test with Daphnia magna.