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EC number: 700-442-0
CAS number: 73573-88-3
The suggested source chemicals, i.e. Lovastatin, Simvastatin,
Simvastatin ammonium and Pravastatin sodium, were considered sufficient
similar in relation to reproductive toxicity and aquatic toxicity to the
target chemical Compactin, to apply the read-across approach. Their
similarity was evaluated in terms of structural, mechanistic,
physicochemical and reactivity similarity. The analysis performed showed
that the structural similarity of the source chemicals Lovastatin and
Simvastatin with respect to the target Compactin is also supported by a
high mechanistic similarity (same profiler results) and high
physicochemical and reactivity similarity. On the other hand,
Simvastatin ammonium and Pravastatin sodium showed a slightly lower
similarity with respect to the target Compactin due to their lower
mechanistic (profiler results) similarity and physicochemical and
reactivity similarity. These results were therefore taken into account,
weighting the experimental test data of Simvastatin ammonium and
Pravastatin less than the ones of the other source chemicals in the
In the current read-across analysis, the target chemical Compactin has
been predicted as DANGEROUS for reproductive toxicity, category
1A,hazard H360 which means that it may damage fertility or the unborn
child and hazard H362, which means that it may cause harm to breast-fed
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