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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study with GLP
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
There is no need to add in this field.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
425-220-8
EC Name:
-
Cas Number:
5945-33-5
Molecular formula:
C39H34O8P2
IUPAC Name:
(1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate
Details on test material:
75 - 95% (typical 88%, verified by UV/visible spectrum, Infrared (IR) spectrum, Nuclear Magnetic Resonance (NMR), and Mass spectrum.)

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
Nothing to add in this field.

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
4 hours
Observation period:
3 days
Number of animals:
3 (males)
Details on study design:
Nothing to add in this field.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 1,24,48,72 hours
Score:
0
Max. score:
0
Reversibility:
no data
Remarks on result:
other: The test material was applied to a prepared site on the dorsal aspect of the animals by a patch held in place by tape
Irritant / corrosive response data:
No signs of irritation/corrosive were noted during the study.
Other effects:
no data

Any other information on results incl. tables

No signs of irritation/corrosive were noted during the study. The test substance produced a primary irritation index of 0.0 for erythema and oedema.

The test chemical was non-irritating to the skin of rabbits.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The test material was non-irritating to the skin of rabbits.
Executive summary:

According to OECD TG 404, the test chemical was considered as a non-irriating substance via acute dermal irritation/corrosion study in rabbits.