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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
report date: 2010-01-06
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
no
Type of method:
thermal analysis
Key result
Melting / freezing pt.:
54.95 °C

Atmospheric pressure during the assay has not been measured; the melting temperature was given without any correction.

Result of the melting point:

 

Test item

Reference item

 

Assay 1

Assay 2

Mean(+/- Standard deviation)

Measure

range

Weight (mg)

5.39

5.45

-

5.09

-

Melting point (°C)

55.0

54.9

54.95 +/- 0.05

121.6

121.3 – 122.7

According to the results of the reference item, the test has to be considered as valid.

Conclusions:
The melting point of 4-TBC is 54.95°C +/- 0.05°C.
Executive summary:

In a study (Processium, 2010), the melting point of 4-tert-butylpyrocatechol (4 -TBC) was assessed using the differential scanning calorimetry, according to the regulation (EC) n°440/2008, A.1, and to the OECD Guideline n°102.

 

A test item amount of 5 mg was heated up from 30 to 300°C with a rate of 10°C/min. During the experiment, two samples were measured. The quantities of heat absorbed or released were measured by Differential Scanning Calorimetry and recorded. A reference sample (around 5 mg) of benzoic acid was measured in order to evaluate the experimental procedure.

The results of the melting point of 4 -TBC were: 55°C and 54.9°C and of the reference item: 121.6°C.

According to the results of the reference item, the test has to be considered as valid.

In conclusion, the melting point of 4 -tert-butylpyrocatechol is 54.95°C +/- 0.05°C.

This study is classified as acceptable and satisfies the guideline requirements for a melting point study.

Description of key information

Melting point: 54.95°C +/- 0.05°C

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
54.95 °C

Additional information

One experimental study (Processium, 2010) with reliability 1 according to Klimisch was available and was selected as key study. Melting point was determined according to the regulation (EC) n°440/2008, A.1.

Data coming from peer-review handbooks were also available. As the values are in the same range, they are used in a supporting approach.