Registration Dossier
Registration Dossier
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EC number: 231-176-9 | CAS number: 7440-67-7
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: unassignable study, only summary available
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of an occupational respiratory exposure to a zirconium containing dust.
- Author:
- Hadjimichael O.C. and Brubaker R.E.
- Year:
- 1 981
- Bibliographic source:
- J Occup Med. 23: 543-547
Materials and methods
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- A group of handfinishers of zirconium metal reactor components questioned whether the dust to which they were exposed would cause chronic lung disease or cancer, or both. To investigate this possibility, the work environment was surveyed, and 32 male employees who had worked as handfinishers from one to seventeen years, were compared to a group of controls in reference to a respiratory questionnaire, chest x-ray findings, and expiratory lung function tests.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Zirconium compounds
- IUPAC Name:
- Zirconium compounds
- Details on test material:
- Zirconium containing dust, without any precision
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- 32 male employees
- Reason of exposure:
- unintentional, occupational
- Details on exposure:
- employees had worked as handfinishers from one to seventeen years
- Examinations:
- Respiratory questionnaire, chest x-ray findings, and expiratory lung function tests.
The controls were matched to the handfinishers for age, sex, payroll status and smoking history
Results and discussion
- Clinical signs:
- No significant differences were found between the exposed and the control groups.
- Results of examinations:
- No significant differences were found between the exposed and the control groups.
Applicant's summary and conclusion
- Conclusions:
- No significant differences were found between the exposed and the control groups.
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