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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Adsorption / desorption

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Administrative data

Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report date:
2004

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
GLP compliance:
yes
Type of method:
HPLC estimation method
Media:
soil

Test material

Constituent 1
Chemical structure
Reference substance name:
(2R)-2-(2-chlorophenyl)-2-hydroxyethanoic acid
EC Number:
444-040-0
EC Name:
(2R)-2-(2-chlorophenyl)-2-hydroxyethanoic acid
Cas Number:
52950-18-2
Molecular formula:
Hill formula: C8H7ClO3 CAS formula: C8H7CLO3
IUPAC Name:
(2R)-2-(2-chlorophenyl)-2-hydroxyacetic acid
Details on test material:
- test substance: (R)-2-Chloromandelic acid
- purity: 99.5%
Radiolabelling:
no

Study design

Test temperature:
25°C

HPLC method

Details on study design: HPLC method:
EQUIPMENT
- Apparatus: Modular HPLC System with UV/vis detector.
- Type, material and dimension of analytical (guard) column: 250 x 3 mm Nucleosil 100-5 CN (Macherey & Nagel)
- Detection system: UV/vis detector


MOBILE PHASES
- Type: water 1 acetonitrile = 9:1 (v/v) with 0.1 vol% H3P04, pH = 2.2
- Experiments with additives carried out on separate columns: no data
- pH: 2.2
- Solutes for dissolving test and reference substances: no data

DETERMINATION OF DEAD TIME
- Method: The dead time of the HPLC-system was measured withformamide.

REFERENCE SUBSTANCES
- Identity: Acetanilide

DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 40 mg of test item was weighed in a 100 ml volumetric flask and dissolved in water/acetonitrile = 9:1 (v/v). This solution was diluted 1:5 with waterlacetonitrile = 9:1 (v/v).
For calibration, small amounts of reference compounds were dissolved in 20 vol% acetonitrile (ultrasonic treatment) and the flask was made up to volume with water.

REPETITIONS
- Number of determinations: no data


Results and discussion

Adsorption coefficientopen allclose all
Type:
Koc
Value:
< 17.78
Type:
log Koc
Value:
< 1.25

Results: Batch equilibrium or other method

Transformation products:
not measured

Any other information on results incl. tables

RS-Freetext:
log Koc < acetanilide (1.25) at 25 °C

Applicant's summary and conclusion

Validity criteria fulfilled:
yes