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EC number: 244-240-6
CAS number: 21145-77-7
The results of the standard plate
incorporation test are summarized in table 1 and of the preincubation
test in table 2.
The spontaneous mutation rate was
within the range observed for historical controls. All positive controls
gave acceptable responses.
Toxic effects were not apparent in the
standard assay, thus a dose range of 8 to 5000 µg/plate was evaluated to
include solutions and suspensions.
AHTN did not cause en increase of the
number of revertant colonies in any of the seven tester strains.
Table I Salmonella mutagenicity test
(standard assay). Mean values and standard deviations.
Table 2 Salmonella
mutagenicity test (Liquid preincubation assay). Mean values and standard
AHTN was investigated for mutagenic
potential using two versions of the Ames test: the standard plate
incorporation and the preincubation methods. Seven tester strains were
employed (S. typhimurium TA1535, TA1537, TA97, TA98, TA100, TA1O2 and E.
coli VP2 uvrA). The cells were exposed to the test compound in absence
and presence of a metabolic activation systent (S9 mix) prepared from
the livers of phenobarbital/8-naphthoflavone treated rats.
Responsiveness of the strains and
activity of the S9 mix were verified by including appropriate positive
The test compound was dissolved in
DMSO. Milky suspensions concentrations of 158 pg/plate and above. The
dose range was chosen 5000 µg/plate. No toxicity was observed up to 5000
No increase of the number of reverting
colonies were observed for any of the seven tester stains.
Thus it can be concluded that neither
AHTN nor any of its metabolites are mutagenic in the Ames test under the
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