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EC number: 244-240-6
CAS number: 21145-77-7
Repeated applications during the induction
produced moderate to strong skin irritation. Therefore, the first
application site had to be changed after a 2 weeks' treatment.
The 1% solution of AHTN caused no primary
irritant skin reactions in the control animals. Challenge tests with the
highest non-irritant solution of AHTN (1%) on days 21 and 35 were
negative for all the induction concentration groups.
AHTN concentrations of 3, 10 or 30% in
ethanol:acetone (50:50) mixtures were applied in 0.1ml doses to 8 cm2
clipped flank skin of 6 guinea pigs per dose. These concentrations
were irritating under the conditions used, hence the application site
was changed after two weeks during the induction phase. The maximal
non-irritating dose was 1%. At the challenge and re-challenge stage two
weeks later, the non-irritating dose was applied to a 2 cm2 naïve
site. Reactions were read 24 and 48 hours after each challenge dose, and
compared to reactions in non-induced control animals. No sensitisation
reactions were observed.
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