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EC number: 244-240-6
CAS number: 21145-77-7
Table 1 Body weight and mortality rate in
rats after a single oral dose administration in rats
Groups of five male and five female
young adult albino rats were administered by gavage 4.00, 4.80, 5.76,
6.91 or 8.29 ml/kg bw of a 17.5% (w/v) solution of AHTN (Tonalid®;
purity =98%; equivalent to doses of 700, 840, 1008, 1209 and 1451 mg/kg
bw AHTN) in isopropyl myristate and observed for 14 days. Within a few
hours, signs of sluggishness and piloerection were seen. Later on
haematuria, encrustrations around eyes and nostrils and signs of
emaciation were observed. Death occurred between 6 hours and 8 days of
dosing at which time survivors recovered gradually looking healthy at
the end of the observation period. Macroscopic examination at autopsy of
the rats that died in the first few days revealed blood stained urine in
the bladder. No other treatment-related gross alterations were seen in
these or other animals. An LD50 of 920 mg/kg bw was calculated.
Source: EU Risk Asssessment Report
AHTN, Luxembourg, Office for Official Publications of the European
Communities, ECB (May 2008)
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