Registration Dossier
Registration Dossier
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EC number: 801-656-8 | CAS number: 1416808-92-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: JMAFF, Japanese Test Guidelines
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- (3E)-2-chloro-3-(hydroxymethylidene)cyclohex-1-ene-1-carbaldehyde
- EC Number:
- 801-656-8
- Cas Number:
- 1416808-92-8
- Molecular formula:
- C8H9ClO2
- IUPAC Name:
- (3E)-2-chloro-3-(hydroxymethylidene)cyclohex-1-ene-1-carbaldehyde
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Doses:
- 2000mg/kg (10ml/kg) body weight (only dosed to females).
200mg/kg (10ml/kg) body weight (dosed to males and females). - No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- other: mortality
- Effect level:
- 2 000 mg/kg bw
- Remarks on result:
- other: 2 of the 3 females died.
- Sex:
- male/female
- Dose descriptor:
- other: mortality
- Effect level:
- > 200 mg/kg bw
- Remarks on result:
- other: None of the 6 animals dosed at 200mg/kg died.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - <= 2 000 mg/kg bw
- Mortality:
- See effect levels above.
- Clinical signs:
- other: The surviving female dosed at 2000mg/kg body weight showed clinical signs throughout the study period. The animals dosed at 200mg/kg had recovered from the symptoms between days 2 and 4, except for staining of the fur, which was observed throughout the st
- Gross pathology:
- Macroscopic post mortem examination of the surviving animals at termination did not reveal any abnormalities. Watery fluid in the uterus, found in one female, is related to a stage in the oestrous cycle and is a normal finding.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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