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EC number: 809-911-5
CAS number: 1431329-07-5
Oral:One 28-day study on rats is available which was conducted according to OECD 407 using rats (Beerens-Heijnen, 2015). The No Observed Adverse Effect Level (NOAEL) for the test substance was established to be 15 mg/kg.
A twenty-eight day repeated dose study was conducted according to OECD
407 using rats (Beerens-Heijnen, 2015).
SPF-bred Wistar rats were treated with the test substance for 28
consecutive days by daily oral gavage at dose levels of 3, 15 and 75
Based on the marked increase in liver weight with hepatocellular
vacuolation up to marked degree and slight hypertrophy in males and
females at 75 mg/kg, a No Observed Adverse Effect Level (NOAEL) for the
test substance of 15 mg/kg was established.
Oral: Significant toxic effects observed at 75 mg/kg bw/day in
28-day animal study.
Therefore in accordance with Regulation (EC) No. 1272/2008 Table
3.9.1 and 3.9.3 the test substance is classified as category 2 for
specific target organ toxicity-repeated exposure endpoint.
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