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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given: comparable to guidelines

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
(substance purity not stated, no data on individual animals reported, no necropsy performed)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Undecanal
EC Number:
203-972-6
EC Name:
Undecanal
Cas Number:
112-44-7
Molecular formula:
C11H22O
IUPAC Name:
undecanal
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): undecanal

Test animals

Species:
rat
Strain:
Sherman
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Fasting period before study: 24 h
- Diet: ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
5000 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Remarks on result:
other: no animals died during the 14 days observation period
Mortality:
not observed
Clinical signs:
other: diuresis was noted

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Under the tested conditions, the substance did not reveal acute oral toxicity, no animal died after single exposure to 5000 mg/kg bw.
Executive summary:

The test item (purity: not stated) was administered to 5 male and 5 female Sherman-Wistar rats by gavage at the limit dose of 5000 mg/kg bw. During the following 14 days observation period only diuresis could be noted, but none of the animals died. The given results lead to a LD50 > 5000 mg test item per kg bw (Shelanski and Moldovan, 1971).

This study was judged to be reliable with restrictions (RL2), due to missing information on substance purity as well as the missing data on the individual animals.