Registration Dossier
Registration Dossier
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EC number: 203-972-6 | CAS number: 112-44-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- year of publication: 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
- Objective of study:
- other: enzyme kinetics of aldehyde dehydrogenase
- Principles of method if other than guideline:
- Aldehyde dehydrogenase (ALDH) was purified to homogeneity from rat hepatic microsomes by column chromatography. The purified protein was then used with different co-factors in a spectrophotometrical activity assay at 340 nm, which monitors the formation of NADH from NAD.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Undecanal
- EC Number:
- 203-972-6
- EC Name:
- Undecanal
- Cas Number:
- 112-44-7
- Molecular formula:
- C11H22O
- IUPAC Name:
- undecanal
- Reference substance name:
- 203-44-7
- IUPAC Name:
- 203-44-7
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): undecanal
Constituent 1
Constituent 2
- Radiolabelling:
- no
Results and discussion
Any other information on results incl. tables
- enzyme kinetics of ALDH for undecanal was determined
- no numerical values are reported, only graphical presentation
- estimated Km ~10 µM
- estimated Vmax ~ 25 nmol of NADH produced min-1(µg Protein)-1
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Undecanal is rapidly oxicised by aldehydedehydrogenases - Executive summary:
In this publication (RL2) the activity of purified aldehyde dehydrogenase from rat hepatic microsomes was measured spectrophotometrically. Michaelis constant (Km) as well as maximal reaction velocity (Vmax) could be determined for undecanal. No numerical values are reported but they can be estimated from a given figure: Km ~10 µM, Vmax ~ 25 nmol/min and µg Protein (Martini and Murray, 1996).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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