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EC number: 700-054-1
CAS number: 70905-68-9
Table 1: Individual skin irritation scores.
The primary skin irritation potential of Triol was investigated by a
topical semi-occlusive application of 0.5 g to 6 cm2 intact left flank
of each of three young adult New Zealand White rabbits according to the
OECD Guideline No. 404. The duration of treatment was four hours. The
scoring of skin reactions was performed 1, 24, 48 and 72 hours after
removal of the dressing. The scores of each animal at the following
reading times (24, 48, 72 hours) were used in calculating the respective
mean values for each type of lesion.
The test article did no elicit any skin reactions at the application
site at any of the observation times (all scores 0). The mean values
from 24 to 72 hours were therefore 0 for erythema and 0 for oedema.
The test article caused no staining of the treated skin.
No corrosive effects were noted on the treated skin of any animal at any
Based upon the referred classification criteria (EEC Commission
Directive 93/21/EEC of April 27, 1993), Triol is considered to be not
irritating to the rabbit skin.
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