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EC number: 700-054-1
CAS number: 70905-68-9
Table 1: Bodyweights of the individual animals during the test
Bodyweights in g
2000 mg/kg bw
The acute oral toxicity of Triol to the rat was tested with the acute
toxic class method according to the OECD Guideline No. 423 and Directive
96/54/EEC B.1 tris. Two groups, each using thre male or three female
HanIbm: WIST (SPF) rats, were treated with Triol at 2000 mg/kg
bodyweight by a single dose via oral gavage. The test article was
suspended in polyethylene glycol (PEG 300) at a concentration of 0.2
g/mL and administered at a volume of 10 mL/kg. The animals were examined
for clinical signs four to five times during day 1 and once daily during
test days 2 -15. Mortality/viability was recorded together with clinical
signs at the same time intervals on test day 1 and then twice daily on
test days 2 -15. Bodyweights were recorded on day 1 before
administration and days 8 and 15. All animals were subjected to necropsy
and examined macroscopically.
No deaths occurred during the study. Dyspnea and weak activity were
noted in one female animal (no. 1) within ten minutes and one hour after
treatment. Slight ruffled fur and weak activity were observed in all
female animals two hours after test article administration. Slight
ruffled fur was noted in all male animals from 2 to 5 hours after
The bodyweight of the animals was within the range commonly recorded for
animals of this strain and age.
No macroscopic findings were observed at necropsy.
The median lethal dose of Triol after single oral administration to rats
of both sexes, observed over a period of 14 days, is: LD50 > 2000 mg/kg
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