Registration Dossier
Registration Dossier
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EC number: 243-317-1 | CAS number: 19794-93-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- June, 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to the prediction of toxicity delivered by the software Tox Boxes 2.9, Acute Toxicity overview indicates value with high reliability index.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In silico prediction.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made
analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert
knowledge of organic chemistry and toxicology. - GLP compliance:
- no
- Test type:
- other: In silico prediction.
Test material
- Reference substance name:
- Trazodone
- EC Number:
- 243-317-1
- EC Name:
- Trazodone
- Cas Number:
- 19794-93-5
- Molecular formula:
- C19H22ClN5O
- IUPAC Name:
- 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 690 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: The acute toxicity overview indicates values with high reliability index by Tox Boxes 2.9 (software for the prediction).
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral toxicity in rat overview indicates values with high reliability index by Tox Boxes 2.9 (software for the prediction).
Predicted LD50 oral in rat = 690 mg/kg.
The substance is classified as harmful if swallowed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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