Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 10.29 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 4
- Remarks on result:
- other: starting pH: 4; pH level after experiment: 4.1
- Water solubility:
- 12.73 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7
- Remarks on result:
- other: starting pH: 7; pH level after experiment: 6.9
- Water solubility:
- > 18.44 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 8.9
- Remarks on result:
- other: starting pH: 9; pH level after experiment: 7.8
- Details on results:
- For the samples mixed with buffer at pH 9, the pH dropped to a pH of 7.8. This is probably due to an insufficient buffer concentration. Because it can be assumed that a further deprotonation of the acid groups in the molecule lead to a further increase solubility, the concentration found in the experiment is given as minimum value.
- Conclusions:
- The water solubility of N,N’-di-L-alanyl-L-cystine was determined using the shake flask method. At ph 4 and 20°C the water solubility is 10.29 g/L and at pH 7 and 20°C the water solubility is 12.73 g/L At pH 9 (20°C) the water solubility is at least 18.44 g/L.
Reference
Description of key information
The water solubility of N,N’-di-L-alanyl-L-cystine was determined using the shake flask method. At ph 4 and 20°C the water solubility is 10.29 g/L and at pH 7 (20°C) the water solubility is 12.73 g/L At pH 9 (20°C) the water solubility is at least 18.44 g/L.
Key value for chemical safety assessment
- Water solubility:
- 12.73 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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