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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Flammability

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Administrative data

Link to relevant study record(s)

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Endpoint:
flammable solids
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: VDI Guideline 2263, Part 1
Version / remarks:
1990
Deviations:
no
Qualifier:
according to guideline
Guideline:
UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)
Version / remarks:
2019
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Key result
Test procedure:
burning rate test: preliminary screening test
Remarks on result:
substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period
Interpretation of results:
not classified based on GHS criteria
Conclusions:
According to UN Test N.1 the test item N,N’-di-L-alanyl-L-cystine / (L-Ala-L-Cys)2 could not be ignited applying a flame as ignition source for at least 2 minutes.
The test item is classified as follows:
UN Transport Regulation: The test item does not have to be classified as readily combustible solid in Class 4, Division 4.1 – Flammable solids according to the UN Transport Regulation.
GHS (CLP Regulation (EC) No 1272/2008: Annex I: 2.7): The test item does not have to be classified as flammable solid according to GHS / CLP Regulation (EC) No 1272/2008: Annex I: 2.7.
Endpoint:
self-heating substances / mixtures
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: VDI Guideline 2263, Part 1
Version / remarks:
1990
Deviations:
no
Qualifier:
according to guideline
Guideline:
UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)
Version / remarks:
2019
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Key result
Test procedure:
other: Grewer Oven
Max. temp. reached:
545
Result:
negative outcome (no effect observed)
Interpretation of results:
not classified based on GHS criteria
Conclusions:
The pure test item N,N’-di-L-alanyl-L-cystine / (L-Ala-L-Cys)2 indicated self-ignition at atmospheric pressure starting at a temperature of 230 °C. Due to the high onset temperature in the Grewer Oven, it can be assumed that the UN Test N.4 using the 100 mm cube sample at 140 °C is negative.
On the basis of the results of the tests on the self-ignition in the Grewer Oven the test item is classified as follows:
UN Transport Regulation: The test item does not have to be classified as self-heating substance in Class 4, Division 4.2 according to the UN Transport Regulation.
GHS / CLP Regulation (EC) No 1272/2008 Annex I: 2.11: The test item does not have to be classified as self-heating substance according to GHS/CLP Regulation (EC) No 1272/2008 Annex I: 2.11.

Description of key information

not flammable (UN Test N.1, GLP)

not self-heating (Grewer oven, GLP)

Key value for chemical safety assessment

Flammability:
not classified

Additional information

According to UN Test N.1 the test item N,N’-di-L-alanyl-L-cystine / (L-Ala-L-Cys)2 could not be ignited applying a flame as ignition source for at least 2 minutes.

The pure test item N,N’-di-L-alanyl-L-cystine / (L-Ala-L-Cys)2 indicated self-ignition at atmospheric pressure starting at a temperature of 230 °C. Due to the high onset temperature in the Grewer Oven, it can be assumed that the UN Test N.4 using the 100 mm cube sample at 140 °C is negative.

Justification for classification or non-classification

According to UN Test N.1 the substance is classified as follows:

UN Transport Regulation: The test item does not have to be classified as readily combustible solid in Class 4, Division 4.1 – Flammable solids according to the UN Transport Regulation.

GHS (CLP Regulation (EC) No 1272/2008: Annex I: 2.7): The test item does not have to be classified as flammable solid according to GHS / CLP Regulation (EC) No 1272/2008: Annex I: 2.7.

On the basis of the results of the tests on the self-ignition in the Grewer Oven the substance is classified as follows:

UN Transport Regulation: The test item does not have to be classified as self-heating substance in Class 4, Division 4.2 according to the UN Transport Regulation.

GHS / CLP Regulation (EC) No 1272/2008 Annex I: 2.11: The test item does not have to be classified as self-heating substance according to GHS/CLP Regulation (EC) No 1272/2008 Annex I: 2.11.