Registration Dossier
Registration Dossier
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EC number: 926-056-4 | CAS number: 914917-99-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation
- Remarks:
- other: in silico
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2014
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- Screening for protein binding alerts with the OECD QSAR Toolbox v3.2 (OASIS profiler v1.2, OECD)
- GLP compliance:
- no
- Type of study:
- other: screening for protein binding alerts
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
The substance is an
α,β-Carbonyl compound with a polarized double bond. This is a mechanistic alert for michael addition on conjugated systems with electron withdrawing groups (profiler OASIS v1.2). The polarised alkene ester is also identified by the OECD profiler to be an alert for nucleophilic subsition and therefore protein binding.
The molecular weight and the calculated log Pow are both in a range for which skin permeability must be assumed.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
