Ethane, 1,2-dichloro-1-[difluoro(trifluoromethoxy)methoxy]-1,2,2-trifluoro-

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

January 2016 - October 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Specific details on test material used for the study:

- Source and batch No.of test material: 15-TV10790
- Expiration date of the batch: 30 November 2020
- Purity test date: 08 september 2015

- Storage condition of test material: In refrigerator (2-8°C)

- Treatment of test material prior to testing: No specific handling conditions required

Key result

Water solubility:

0.838 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

7

Details on results:

1) Preliminary test:
The content of test item dissolved in the water sample was 0.00118 g/L (analysis using the 2 mL sample) and 0.00129 g/L (analysis using the 0.25 mL sample). These results are considered comparable.

2) Main study:
The results for the samples taken at 24, 48 and 72 hours are given in the table 1 in "Any other inforamtion including tables".

The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15%. Based on this it was concluded that the samples analysed did not contain undissolved material. The water solubility of the test item is given as the mean value of the analysed concentrations. No test item was detected in the pretreated sample from the blank water mixture. The water solubility of the test item at 20°C was 0.000838 g/L.

Tables 1: Main study - water solubility of the test item

Stirring time [Hours]	Analysed concentration [g/L]	Mean [g/L]	MD [%]	pH
24	0.000810	0.000838	6.0	7.0
48	0.000843			7.0
72	0.000861			7.1

Conclusions:

The slow-stirring flask method was applied for the determination of the water solubility of 1,2-dichloro-1-[difluoro(trifluoromethoxy)methoxy]-1,2,2-trifluoroethane (CAS 874288-98-9).
The water solubility of the test item at 20°C was 0.000838 g/L.
The pH of the aqueous samples was 7.0 - 7.1.

Executive summary:

The water solubility of 1,2-dichloro-1-[difluoro(trifluoromethoxy)methoxy]-1,2,2-trifluoroethane (CAS 874288-98-9) was determined using the slow-stirring flask method according to the OECD guideline 105 (1995) and in compliance with GLP guidelines.

The water solubility of the test item was found to be 0.000838 g/L at 20°C.

Description of key information

One reliable key study (Klimisch 1) is available. The water solubility of the test item was determined using the slow-stirring flask method according to the OECD guideline 105 (1995) , the EU Mtehod A.6 and in compliance with GLP guidelines.

No deviations from the guidelines were observed during the test.

Key value for chemical safety assessment

Water solubility:

0.838 mg/L

at the temperature of:

20 °C