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Diss Factsheets
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EC number: 231-810-4 | CAS number: 7747-35-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Three acute fish toxicity tests were conducted with EDHO. The most recent study was conducted according to the OECD 203 fish toxicity guideline. The two older tests were conducted according to USEPA-660/ASTM, which were similar to the OECD 203 guideline. All three tests were conducted under the auspices of GLP guidelines but only the most recent included analytical verification of exposure concentrations.
The key study for the acute fish toxicity endpoint is the most recent rainbow trout test. This test was conducted using flow-through conditions to maintain concentrations of the parent EDHO. Analytical verification of test solutions was conducted and demonstrated that test concentrations averaged about 80% of target and remained stable for the duration of the exposure. The results are calculated based on mean measured concentrations. The 96-hour LC50 was 244 mg EDHO/L.
The two remaining tests were conducted under static conditions. These tests were conducted as static exposures in contrast to the more study which was conducted under flow-through conditions. The older (1982) rainbow trout study determined a 96-hour LC50 of 240 mg/L based on nominal concentrations. The bluegill sunfish study determined a 96-hour LC50 of 130 mg EDHO/L, based on nominal concentrations.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 130 mg/L
Additional information
Three freshwater acute fish toxicity tests were conducted with EDHO. The most recent test (2007) was the key study. The most recent of the three tests (2007) was conducted under GLP with a flow-through exposure and analytical verification of exposure concentrations using rainbow trout (Oncorhynchus mykiss). The two older tests were static exposures conducted under GLP using bluegill (Lepomis macrochirus) and rainbow trout, but lacked analytical verification of exposure concentrations. The 96 -hour LC50 values determined on these tests were 130, 240, and 244 mg EDHO/L, respectively, for the bluegill, rainbow trout (1982), and rainbow trout (2007) studies. The 2007 rainbow trout study was chosen as the key study as it was conducted with analytical verification and the exposure was flow-through. The similarity in acute toxicity determined between the two rainbow trout studies indicates that the toxicity seen in the bluegill acute study was accurate, even with the lack of analytical verification. As a result, the bluegill LC50 value was chosen as the key acute fish toxicity value for the chemical safety assessment.
These results indicate that EDHO is not dangerous to freshwater fish species.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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