Registration Dossier
Registration Dossier
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EC number: 231-096-4 | CAS number: 7439-89-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Studies on the effects of metallic iron on fertility are waived on the ground that these effects depend entirely on systemic exposure. Systemic exposure of iron can be ruled out, owing to the negligible solubility of the substances in aqueous and organic solvents. There is no significant systemic exposure after inhalation or dermal contact, the relevant exposure routes in the present context. Oral exposure is restricted to food fortification, supplementation and medicinal use. The strict regulation of iron absorption and storage in healthy humans will also prevent the systemic occurrence of free iron ions.
Effects on developmental toxicity
Description of key information
Studies on the developmental/teratogenic effects of metallic iron are waived on the ground that these effects depend entirely on systemic exposure. Systemic exposure of iron can be ruled out, owing to the negligible solubility of the substances in aqueous and organic solvents. There is no significant systemic exposure after inhalation or dermal contact. . Oral exposure is restricted to food fortification, supplementation, and medicinal use. The strict regulation of iron absorption and storage in healthy humans will also prevent the systemic occurrence of free iron ions
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No classification justified, because possible endpoints require systemic exposure, which will be negligible after inhalation or dermal exposure. Oral exposure only occurs on purpose by food fortification/supplementation and in a medicinal context. Moreover, the strict regulation of iron absorption and storage in healthy humans will also prevent the systemic occurrence of free iron ions and thereby effects on relevant endpoints.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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