Registration Dossier
Registration Dossier
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EC number: 209-170-2 | CAS number: 557-34-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Basic toxicokinetics: Key study: Absorption is faster with low intragastric pH. The mean plasma zinc area under the curve for zinc acetate at low pH and at high pH were 524 and 378 µg/h/dL, respectively.
Key value for chemical safety assessment
Additional information
Basic toxicokinetics:
Key study: Absorption is faster with low intragastric pH. The mean plasma zinc area under the curve for zinc acetate at low pH and at high pH were 524 and 378 µg/h/dL, respectively.
Discussion on bioaccumulation potential result:
Key study: Experimental data:
Healthy subjects were given a single oral dose of 50 mg elemental zinc as the acetate salt under either high (pH > 5) or low (pH < 3) intragastric pH conditions.
The mean plasma zinc area under the curve for zinc acetate at low pH and at high pH were 524 and 378 µg/h/dL, respectively. Absorption is faster with low intragastric pH.
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