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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
presumably 1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Only results given. Publication has lack of methodical details
Qualifier:
no guideline followed
Principles of method if other than guideline:
1.) 3 male albino rabbits were used. The abdomen were closely clipped and 1 mL/kg bw was placed on the intact skin daily for 4 days. The animals were observed daily and for a period of 36 h after the last application.

2.) 3 male albino rabbits were used. 1 mL/kg was placed on the closely clipped abdomen for a total of 18 applications (6 d per week). Animals were observed daily and for a period of two weeks following the last application.

GLP compliance:
not specified
Species:
rabbit
Strain:
other: Albino
Details on test animals or test system and environmental conditions:
no further data
Type of coverage:
not specified
Preparation of test site:
other: intact / abraded
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
1 mL/kg bw (ca. 1000 mg/kg)
Duration of treatment / exposure:
4 - 18 applications
Observation period:
36 h to 2 weeks after last application
Number of animals:
2-3
Details on study design:
see above
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritant effects noted

Individual scores were not given. Examination time points: 36 h to 2 weeks after last application.

The skin irritation potential of Acetyl Triethyl Citrate was evaluated using three male albino rabbits. The test substance (1 cc/kg body weight) was inuncted onto intact abdominal skin that had been clipped free of hair. This procedure was repeated daily for 4 days. The animals were observed daily for up to 36 hours after the last application. Acetyl Triethyl Citrate did not induce skin irritation in any of the three rabbits tested .

In another study, Acetyl Triethyl Citrate (1 cc/kg body weight) was inuncted onto intact abdominal skin of each of three male albino rabbits for a total of 18 applications (6 days/week). The animals were then observed over a period of 2 weeks. Body weights were normal throughout the study. Skin irritation was not observed in any of the animals .

Interpretation of results:
GHS criteria not met
Conclusions:
ATEC was not skin irritating. Classification criteria are not meet.
Executive summary:

In all of the 2 trials there was no indication for skin irritation.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
presumably 1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Methodical details are missing
Qualifier:
no guideline followed
Principles of method if other than guideline:
3 male albino rabbits were used. 0.1 mL was instilled once into the left conjunctival sac, while the right eyes were used as controls. Observations were made at 20 min and at 3 – 72 h after application.
GLP compliance:
not specified
Species:
rabbit
Strain:
other: Albino
Details on test animals or tissues and environmental conditions:
no data
Vehicle:
not specified
Controls:
other: right eyes were used as controls
Amount / concentration applied:
0.1 mL
Duration of treatment / exposure:
single application
Observation period (in vivo):
Observations were made at 20 min and at 3 – 72 h after application.
Number of animals or in vitro replicates:
3 m
Details on study design:
SCORING SYSTEM: no data
Remarks on result:
other: Transient erythema (slight to moderate) of the palpebral conjunctivae was observed in two of the three rabbits. After 24 hours, the erythema was described as negligible.

Transient erythema (slight to moderate) of the palpebral conjunctivae was observed in two of the three rabbits. After 24 hours, the erythema was described as negligible.

Interpretation of results:
GHS criteria not met
Conclusions:
ATEC was slightly eye irritating. However, classification criteria are not meet.
Executive summary:

3 male albino rabbits were used. 0.1 mL was instilled once into the left conjunctival sac, while the right eyes were used as controls. Observations were made at 20 min and at 3 – 72 h after application. Transient erythema (slight to moderate) of the palpebral conjunctivae was observed in two of the three rabbits. After 24 hours, the erythema was described as negligible.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

Based on the results of the available experiments, classification criteria are not met.