Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
232-382-1
CAS no.:
8012-00-8
Index number:
Molecular formula:
O7Pb2Sb2
SMILES:
[Pb++].[Pb++].[O-][Sb]([O-])(=O)O[Sb]([O-])([O-])=O
InChI:
InChI=1S/7O.2Pb.2Sb/q;;;4*-1;2*+2;;
Type of substance:
UVCB
Origin:
Inorganic
Registered compositions:
8
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance may damage the unborn child and is suspected of damaging fertility, is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, is harmful if swallowed, is harmful if inhaled and may cause damage to organs through prolonged or repeated exposure.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may damage fertility or the unborn child, causes damage to organs through prolonged or repeated exposure and is suspected of causing cancer.

Breakdown of all 12 C&L notifications submitted to ECHA

Repr. 1A H360Df Harmonised Classification
Aquatic Chronic 1 H410 Harmonised Classification
STOT RE 1 H372
Carc. 2 H351
STOT RE 2 H373 Harmonised Classification
Aquatic Acute 1 H400 Harmonised Classification
Acute Tox. 4 H302 Harmonised Classification
Acute Tox. 4 H332 Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • R
Officially recognised in the EU as Toxic to Reproduction (Harmonised C&L, Candidate list of SVHCs).
  • R
There is broad agreement in that a majority of data submitters agree this substance is Toxic to Reproduction (100% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 2 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Substance of very high concern (SVHC) and included in the candidate list for authorisation.
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):
Some uses of this substance are restricted under Annex XVII of REACH.

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
This substance is subject to the Prior Informed Consent regulation and to export notification procedure from 01-Feb-2016
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 to < 10 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: in the production of articles. Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance can be found in complex articles, with no release intended: Vehicles (e.g. personal vehicles, delivery vans, boats, trains, metro or planes)) and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines). This substance can be found in products with material based on: stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material) and metal (e.g. cutlery, pots, toys, jewellery).

This substance is used in the following products: anti-freeze products, coating products, inks and toners and fillers, putties, plasters, modelling clay.

This substance is used in the following areas: building & construction work. This substance is used for the manufacture of: mineral products (e.g. plasters, cement).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles, mixing in open batch processes, non-industrial spraying, treatment of articles by dipping and pouring, hand mixing with intimate contact only with personal protective equipment available, handling of solid inorganic substances (e.g. ores and raw metal oxides, packaging/mixing/blending and weighing of metal powders) and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following products: coating products, inks and toners and fillers, putties, plasters, modelling clay.

This substance is used in the following activities or processes at workplace: mixing in open batch processes, transfer of substance into small containers, handling of solid inorganic substances (e.g. ores and raw metal oxides, packaging/mixing/blending and weighing of metal powders), transfer of chemicals at dedicated facilities, laboratory work and manual maintenance (cleaning and repair) of machinery.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: coating products, fillers, putties, plasters, modelling clay and inks and toners.

This substance is used in the following areas: building & construction work. This substance is used for the manufacture of: mineral products (e.g. plasters, cement), fabricated metal products, electrical, electronic and optical equipment and machinery and vehicles.

This substance is used in the following activities or processes at workplace: mixing in open batch processes, industrial spraying, transfer of substance into small containers, roller or brushing applications, treatment of articles by dipping and pouring and the low energy manipulation of substances bound in materials or articles.

Release to the environment of this substance can occur from industrial use: in the production of articles.

This substance is used in the following activities or processes at workplace: transfer of substance into small containers, handling of solid inorganic substances (e.g. ores and raw metal oxides, packaging/mixing/blending and weighing of metal powders), closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • COLORES CERAMICOS DE TORTOSA, S.A., Pol. Ind Baix Ebre, 154-160 Apartado 37 E-43500 Tortosa Tarragona Spain
  • Ferro GmbH, Gutleutstr.215 60327 Frankfurt am Main Germany
  • Johnson Matthey plc, 5th Floor, 25 Farringdon Street EC4A 4AB London United Kingdom

Substance names and other identifiers

C.I. Pigment Yellow 41
This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77588.
Other
Lead antimonate yellow pyrochlore
This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77588.
Other
Lead antimony yellow pyrochlore
This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77588.
Other
Pyrochlore, antimony lead yellow
EC Inventory, Candidate list, PIC, REACH pre-registration, Other, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances
Pyrochlore, antimony lead Yellow
This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77588.
Candidate list, PIC, REACH pre-registration, Other, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances
Antimony lead oxide
C&L Inventory
bis(lambda2-lead(2+)) {[dioxido(oxo)stibanyl]oxy}(oxo)stibonite
Other
Lead antimony pyrochlore
Registration dossier
Pyrochlore, antimony lead yellow
C&L Inventory, Registration dossier
Pyrochlore, antimony lead yellow
C&L Inventory, Registration dossier
1H6008
Registration dossier
1H9007/F
Registration dossier
1H9011
Registration dossier
1H9018/F
Registration dossier
1H9019/F
Registration dossier
12710-25-7
CAS number
Other
68187-20-2
CAS number
Other
8012-00-8
CAS number
EC Inventory, C&L Inventory, Candidate list, PIC, Registration dossier, REACH pre-registration, Other, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Powder (100%) [1]
C Odour
Odourless (100%) [1]
C Substance type
Inorganic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 1 study submitted
  • 1 study processed
R Melting / freezing point
1 300 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 1 study submitted
  • 1 study processed
R Density
7.81 g/cm³ @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
7.81

Vapour pressure

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Partition coefficient

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Water solubility

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Data not provided by the registrant

Viscosity

Data not provided by the registrant

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Data not provided by the registrant

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Data not provided by the registrant

Bioaccumulation: aquatic / sediment

Data not provided by the registrant

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Data not provided by the registrant

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 2.4 µg/L (1)
Intermittent releases (freshwater) -
Marine water 3.3 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 100 µg/L (1)
Sediment (freshwater) 186 mg/kg sediment dw (1)
Sediment (marine water) 168 mg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 212 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 10.9 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 54 studies submitted
  • 46 studies processed
P/RResults
LC50 (49 days) 280.2 µg/L [1]
LC50 (4 days) 40.8 - 40 540 µg/L [72]
LC50 (48 h) 114 - 610 µg/L [4]
LC10 (49 days) 55.6 µg/L [1]
LC10 (4 days) 304.3 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 8
Weight of evidence 45
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 46 studies submitted
  • 30 studies processed
P/RResults
NOEC (3 months) 48 µg/L [1]
NOEC (84 days) 39.4 - 176.3 µg/L [2]
NOEC (62 days) 87 µg/L [1]
NOEC (60 days) 70 - 136 µg/L [2]
NOEC (53 days) 13.3 - 26.8 µg/L [3]

Type of Study provided
Studies with data
Key study 24
Supporting study 16
Weight of evidence 6
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 96 studies submitted
  • 66 studies processed
P/RResults
LC50 (4 days) 35 - 6 820 µg/L [53]
LC50 (48 h) 26 - 3 115.8 µg/L [42]
LC50 (24 h) 280 - 27 850 µg/L [2]
EC10 (72 h) 111.2 - 252.3 µg/L [4]
EC10 (48 h) 9.2 - 1 409.6 µg/L [7]

Type of Study provided
Studies with data
Key study 8
Supporting study 30
Weight of evidence 58
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 76 studies submitted
  • 47 studies processed
P/RResults
NOEC (4.2 months) 143.3 - 757.2 µg/L [2]
NOEC (4 months) 12 µg/L [1]
NOEC (42 days) 5.9 - 63 µg/L [4]
NOEC (34 days) 109 µg/L [1]
NOEC (30 days) 14 - 31 µg/L [3]

Type of Study provided
Studies with data
Key study 34
Supporting study 29
Weight of evidence 13
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 31 studies submitted
  • 9 studies processed
P/RResults
EC50 (72 h) 20.5 - 364 µg/L [15]
EC50 (48 h) 21.7 - 388 µg/L [8]
NOEC (4 days) 22.7 - 192.3 µg/L [2]
LOEC (4 days) 44.3 - 298.1 µg/L [2]
EC10 (4 days) 29.4 - 1 231.8 µg/L [4]

Type of Study provided
Studies with data
Key study 9
Supporting study 22
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
EC50 (7 days) 1.07 - 8.53 µmol/L [7]
IC10 (7 days) 29.5 - 643.2 µg/L [6]
IC10 (7 days) 0.148 - 6.22 µmol/L [7]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to microorganisms

Study results
  • 28 studies submitted
  • 3 studies processed
P/RResults
IC50 (9 h) 180 mg/L [1]
EC10 (24 h) 7 mg/L [1]
IC10 (24 h) 1 - 2.79 mg/L [3]
IC10 (60 min) 2.92 - 9.59 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 15 1
Weight of evidence 9
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
1 mg/L

Sediment toxicity

Study results
  • 16 studies submitted
  • 13 studies processed
P/RResults
NOEC (35 days) 1 699 mg/kg sediment dw [2]
NOEC (28 days) 503 - 4 719 mg/kg sediment dw [12]
NOEC (21 days) 1 126 - 2 903 mg/kg sediment dw [5]
NOEC (20 days) 3 390 - 5 230 mg/kg sediment dw [2]
LOEC (35 days) 2 734 mg/kg sediment dw [2]

Type of Study provided
Studies with data
Key study 13
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 17 studies submitted
  • 10 studies processed
P/RResults
NOEC (3.733 months) 130 - 564 mg/kg soil dw [3]
NOEC (56 days) 468 - 2 202 mg/kg soil dw [4]
NOEC (28 days) 400 - 6 078 mg/kg soil dw [6]
NOEC (21 days) 608 mg/kg soil dw [1]
EC10 (84 days) 2.03 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 10
Supporting study 7
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 8 studies submitted
  • 7 studies processed
P/RResults
EC10 (35 days) 360 - 1 200 mg/kg soil dw [2]
EC10 (28 days) 193 - 4 718 mg/kg soil dw [19]
NOEC (42 days) 400 - 3 000 mg/kg soil dw [3]
NOEC (36 days) 750 mg/kg soil dw [1]
NOEC (28 days) 34 - 7 020 mg/kg soil dw [6]

Type of Study provided
Studies with data
Key study 7
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 20 studies submitted
  • 15 studies processed
P/RResults
NOEC (4.433 months) 150 mg/kg soil dw [1]
NOEC (42 days) 150 - 287 mg/kg soil dw [2]
NOEC (30 days) 527 - 722 mg/kg soil dw [2]
NOEC (21 days) 374 - 7 190 mg/kg soil dw [8]
NOEC (5 days) 89 - 169 mg/kg soil dw [4]

Type of Study provided
Studies with data
Key study 15
Supporting study 3
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 35 studies submitted
  • 22 studies processed
P/RResults
NOEC (1.726 years) 8.042 g/kg soil dw [2]
NOEC (1.534 years) 8.13 g/kg soil dw [2]
NOEC (10.033 months) 163 mg/kg soil dw [2]
NOEC (28 days) 100 - 810 mg/kg soil dw [4]
NOEC (21 days) 500 - 3 800 mg/kg soil dw [4]

Type of Study provided
Studies with data
Key study 12
Supporting study 12
Weight of evidence 10
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 14 studies submitted
  • 14 studies processed
P/RResults
NOEC (7 months) 50 mg/kg diet [3]
NOEC (84 days) 25 - 2 000 mg/kg diet [7]
NOEC (75 days) 100 mg/kg diet [4]
NOEC (70 days) 200 mg/kg diet [1]
NOEC (60 days) 264 mg/kg diet [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 14
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
100 mg/kg food

Toxicity to mammals

Study results
  • 13 studies submitted
  • 13 studies processed
P/RResults
NOEC (1.227 years) 550 mg/kg diet [2]
NOEC (1.159 years) 64 mg/kg diet [1]
NOEC (11.1 months) 512 mg/kg diet [1]
NOEC (6.3 months) 1 000 mg/kg diet [3]
NOEC (84 days) 1 000 mg/kg diet [3]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 13
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: High hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: High hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: High hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 2
Weight of evidence 2
Other
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 9 studies submitted
  • 9 studies processed
P/RResults
LD50 2 000 - 5 000 mg/kg bw (rat) [9]
M/CInterpretations of results
GHS criteria not met [2]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study
Weight of evidence 7
Other
Data waiving
no waivers
inhalation
  • 2 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 h) 5.05 - 5.11 mg/L air (rat) [2]
M/CInterpretations of results
Not classified [1]

inhalation
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 3 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [3]
M/CInterpretations of results
Other [3]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 2 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 5 000 mg/m³
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: eye
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 2 studies submitted
  • 2 studies processed
P/RResults
LOAEL (rat): 200 ppm [1]
NOEL (rat): 0.002 mg/kg bw/day [1]
LOEL (rat): 0.005 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study
Supporting study 12 1
Weight of evidence 5
Other
Data waiving
no waivers
Study data: in vivo
  • 17 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 5
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No study available

Carcinogenicity

Study results
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 9
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed NOAEL 7.8 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: developmental
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant