Registration Dossier
Registration Dossier
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EC number: 941-187-7 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The key study for skin irritation reports a mean 24/48/72h score of 2 for erythema and 1.3 for edema after a 4 hour semi-occlusive exposure of the test material to rabbit skin (Prinsen 1998; rel 1). The key study for eye irritation reports the 24/48/72 h score to be zero in all animals (Sasol, 1998; rel 1).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The supporting studies for skin irritation include two 24 hour occlusive exposures (Shell 1966; rel 2 and Cassidy and Clark, 1978; rel 2). Shell (1966) reports the test substance to be mildly irritating to skin. Cassidy & Clark (1978) reports an increase in oedema by day 7, with mean scores of 2. The persistence of the irritant response is likely to be the result of the non-standard conditions (24 hours instead of 4, occluded instead of semi-occluded). All other supporting studies for both skin and eye irritation, are in agreement with the key findings.
The presence of branched structures does not appear confer it any different toxicological properties compared to the Alcohols, C12 -13 linears only substance. Therefore the data is freely read-across between Alcohols, C12 -13 -branched and Alcohols, C12 -13 substances.
In some cases the CAS and chemical identity stated refer to SDA nomenclature for this substance. In REACH substance identification it is necessary to be more specific as to the chain lengths present. Full details may be found in the CSR.
Justification for classification or non-classification
Based on the available information, no classification or labelling is required for Alcohols, C12 -13-branched and linear in accordance with EC regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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