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EC number: 413-110-2
CAS number: 135861-56-2
Based on measurements made for physical chemistry properties and qualitative observations for systemic toxicology, the test substance is considered to have only a low potential for absorption and bioaccumulation.
The low water solubility of the substance (0.0476 mg/l), its relatively
high molecular weight (414.49) and moderate water/octanol partition
coefficient (Log Kow 2.78-3.5) indicates that, on balance, the test
substance has a potential for low bioavailability.
The low potential for absorption via the gastro-intestinal tract is
supported by the mild systemic effects apparent at high dosages in
sub-acute and sub-chronic oral toxicity studies in rats.(Section 5.6.3)
and the complete absence of effects following acute oral exposure
(Section 5.2.3). A limited uptake via the lymphatic system cannot be
The test substance is a dimethyl benzylidene derivative of sorbitol,
.The four ether bonds would be expected to be relatively stable, so the
primary metabolic pathway would probably be via the oxidation of the
sorbitol carbon chain to give diols, dicarboxylic acids or a combination
of the two. . The residual benzylidine moiety, alcohols and carboxylic
acids could be conjugated with glucuronic acid to give hydrophilic
metabolites that would be readily excreted. None of the metabolites
formed by these processes would be considered to have any genotoxic
There is no toxicological evidence of distribution to the central
nervous system, but the moderate water/octanol partition coefficient
would indicate slight potential for tissue accumulation.
The absence of systemic effects following acute dermal exposure to the
test material (Section 5.2.3) indicates that no significant absorption
occurs through the skin, and the very low vapour pressure and modest
particle size (median diameter 14µm) suggests that the air concentration
of the substance available for absorption via the lungs would be low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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